The phosphatase pac1
Webb1 apr. 2008 · DUSP1 is a phosphatase, which has also been called CL100, MKP1, 3CH134, or Erp. DUSP1 was originally cloned as CL100 by subtraction hybridization using cells treated with hydrogen peroxide ( 13, 14 ). DUSP1 encodes a dual threonine/tyrosine phosphatase that specifically dephosphorylates and inactivates MAPKs ( 15 ). WebbIn some embodiments, the analog selective for PAC1 may be an antagonist of PAC1 receptor. In some embodiments, an analog selective to PAC1 receptor means that the analog may bind to VPAC2 or VPAC1 receptors but has a higher binding affinity for a domain of the PAC1 receptor if the analog is exposed to to PAC1, VPAC1 receptor and …
The phosphatase pac1
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Webb13 jan. 2024 · PAC1 is selectively upregulated in exhausted tumor-infiltrating lymphocytes and is associated with poor prognosis of patients with cancer. PAC1 hi effector T cells … WebbHere we show that during apoptosis, p53 activates transcription of PAC1 by binding to a palindromic site in the PAC1 promoter. PAC1 transcription is induced in response to serum deprivation and oxidative stress, which results in p53-dependent apoptosis, but not in response to γ-irradiation, which causes cell cycle arrest5,6.
WebbYLADGDLHSDGPGR related products. MedChemExpress provides thousands of inhibitors, modulators and agonists with high purity and quality, excellent customer reviews, precise and professional product citations, tech support and prompt delivery. Webb13 jan. 2024 · 磷酸酶pac1作为t细胞抑制剂，减弱宿主抗肿瘤免疫，这一成果由北京大学尹玉新团队取得。相关论文在线发表在2024年1月13日的《自然—免疫学》上。
http://wirdahl.com/category/phosphoinositide-3-kinase/ Webb13 jan. 2024 · 2015年，尹玉新教授课题组在Nature Immunology发表研究论文，揭示了PAC1通过调控转录因子STAT3活性抑制Th17细胞分化，从而抑制自身免疫性疾病的发 …
WebbPAC-1 activates procaspase-3 with an EC 50 of 2.08 μM. PAC-1 exhibits an enhanced zinc chelating ability (EC 50 = 7.08 μM). PAC-1 induces leukemia cell death with IC 50 of 4.03 …
Webb27 juni 2002 · SOLUTION STRUCTURE OF THE CATALYTIC DOMAIN OF MAPK PHOSPHATASE PAC-1: INSIGHTS INTO SUBSTRATE-INDUCED ENZYMATIC … optic lobe frogWebb14 jan. 2024 · Cancer cells subvert immune surveillance through inhibition of T cell effector function. Elucidation of the mechanism of T cell dysfunction is therefore central to cancer immunotherapy. Here, we report that dual specificity phosphatase 2 (DUSP2; also known as phosphatase of activated cells 1, PAC1) acts as an immune checkpoint in T cell … optic lobeWebb1 jan. 1998 · Calcineurin is a highly conserved and ubiquitously expressed Ca 2+ - and calmodulin-dependent protein phosphatase. The in vivo role of calcineurin, however, is not fully understood. Here, we show that disruption of the calcineurin gene (ppb1 +) in fission yeast results in a drastic chloride ion (Cl −)-sensitive growth defect and that a high copy … optic longvicWebb19 mars 1993 · PAC-1 is similar to a phosphatase induced by mitogens or heat shock in fibroblasts, a yeast gene, and a vaccinia virus-encoded serine-tyrosine phosphatase … optic liveWebbThis research was planned to explore effects of cerium oxide nanoparticles (nanoceria) on human platelet functions and whole blood coagulation. optic lightsWebb4 dec. 2009 · Ward et al. (1994) demonstrated that PAC1 is a dual-specific thr/tyr phosphatase that is a physiologically relevant MAP kinase phosphatase. Yin et al. (2003) … optic linkWebbPAC1 is selectively upregulated in exhausted tumor-infiltrating lymphocytes and is associated with poor prognosis of patients with cancer. PAC1hi effector T cells lose … portholland partnership