Sin3b cancer

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August undefined, 2024

Webb29 sep. 2014 · While Sin3B is dispensable for cell survival and proliferation in primary fibroblasts, it is required for entry into quiescence upon serum withdrawal, and for entry into cellular senescence... Webb9 okt. 2024 · Sin3B serves as a scaffold for chromatin-modifying complexes that repress gene transcription to regulate distinct biological processes. Sin3B-containing complexes …

SIN3B (SIN3 transcription regulator family member B)

Webb10 nov. 2016 · These observations suggest that Sin3B functions as a non-classical tumor suppressor which serves to limit the transformative potential of cancer cells. The restoration of Sin3B functionality and downstream pathways may prove useful in the design of targeted therapies to treat advanced disease. Webb12 aug. 2009 · Importantly, expression of Sin3B increases upon oncogenic stress, both in vitro and in vivo, correlating with the induction of the senescence program, but is … phoenix orange beach condo rental

Sin3B Expression Is Required for Cellular Senescence and Is Up ...

WebbSubcellular - SIN3B - The Human Protein Atlas SIN3B SUBCELLULAR RNA EXPRESSION HUMAN CELLS ANTIBODIES AND VALIDATION Dictionary Nucleoplasm Plasma membrane Subcellular proteome Nucleoplasm Plasma Membrane All non detected compartments SIN3B detected in Nucleoplasm and Plasma membrane ASSAYSi Webb29 aug. 2024 · This finding reveals a largely unexplored function for Sin3b in the nervous system. Sin3 is not essential for viability in S. cerevisiae (Sternberg et al., 1987) but Drosophila sin3 and murine Sin3a and Sin3b mutants are lethal (Pennetta and Pauli, 1998; Cowley et al., 2005; Dannenberg et al., 2005; David et al., 2008; Sharma et al., 2008 ). WebbSIN3B. The antibodies are designated mAB for monoclonal and pAb for polyclonal. The release of the Human Protein Atlas in which the antibody was first published. All assays through which the antibody has been validated. Assays&annotation provide a detailed description of the different assays. The pie-charts indicate degree of validation. phoenix orange beach al airbnb

Expression of SIN3B in cancer - Summary - The Human Protein Atlas

Webb1 okt. 2024 · SIN3B has been implicated in the initiation of senescence in vitro Here we show that in a mouse model of prostate cancer, SIN3B provides a barrier to malignant … Webb1 jan. 2016 · Sin3B also interacts with an E3 ubiquitin ligase, RNF220 that targets Sin3B for ubiquitination and promotes its proteasomal degradation (Kong et al., 2010). Recently … ttpost chairmanWebb1 okt. 2024 · SIN3B has been implicated in the initiation of senescence in vitro. Here we show that in a mouse model of prostate cancer, SIN3B provides a barrier to malignant progression. SIN3B was required for … ttpost claxton bay

"Webb5 jan. 2024 · Sin3B is required for the competitive repopulation capacity of HSCs. (A) Schematic for serial competitive repopulation assay. ... E2F4, and the pocket proteins Rb1, p107, and p130. 32 Work in cancer cell lines and fibroblasts demonstrated that Sin3B, along with HDAC1, ... " - Sin3b cancer

Sin3b cancer

Abstract A15: Sin3B: a non-classical tumor suppressor

Webb1 jan. 2016 · Sin3A/B are global transcription regulators that provide a versatile platform for diverse chromatin-modifying activities. Sin3 proteins regulate key cellular functions that include cell cycle, proliferation, and differentiation, and have recently been implicated in cancer pathogenesis. WebbCANCER ATLAS. Gene description. SIN3 transcription regulator family member B: Protein class. Predicted intracellular proteins: Protein evidence. Evidence at protein level

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Webb4 dec. 2024 · Human cancer cells lacking Sin3B were, however, able to enter quiescence normally and progress through the cell cycle with normal kinetics. Strikingly, ectopic expression of the APC/C CDH1 inhibitor EMI1 was sufficient to promote cell-cycle re-entry of Sin3B deleted cells under serum-deprived conditions, while the Sin3B wild-type cells … WebbWe previously demonstrated that the histone deacetylase-associated protein SIN3B is essential for oncogene-induced senescence in cultured cells. Here, using a mouse model …

Webb5 aug. 2015 · SIN3A and SIN3B, which lack intrinsic DNA-binding activity, serve as molecular scaffolds that bridge interactions between chromatin regulators and …

Webb11 nov. 2014 · We concluded that Sin3B was required for both KRas-induced senescence and inflammation in vivo, and that entry into senescence surprisingly correlated with … Webb14 aug. 2024 · Oncomine expression analysis using two independent studies showed that SIN3B is significantly downregulated in carcinoma compared to normal prostate tissue, and that SIN3B lies among the top 10% most downregulated transcripts in prostate cancer (ranked 1,384 out of 22,238 genes and 83 out of 8,603 genes, respectively) (Fig. 6A, B).

WebbSin3B was associated with delayed PDAC progression and correlated with an impaired inflammatory response. In murine and human pancreatic cells and tissues, levels of …

WebbSIN3B TISSUE CELL PATHOLOGY PATHOLOGY ATLAS GENE/PROTEIN ANTIBODIES AND VALIDATION Dictionary PROGNOSTIC SUMMARYi Prognostic marker in prostate cancer … phoenix orange beach webcamsWebb29 mars 2024 · Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression the essential role of Sin3B as an important associate of p53 in … ttporky twitchWebb8 dec. 2024 · Sin3B is required for the senescent phenotype and elevated levels of reactive oxygen species elicited upon Bmi-1 depletion. Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression interaction with Sin3B influences Na (v)-channel trafficking or stability in the membrane. phoenix orange beach westWebbHuman hepatocellular carcinoma (HCC) is the sixth most common cancer and the fourth leading cause of cancer-related death worldwide, and the incidence of HCC has been on the rise in recent decades. [ 1 , 2 ] Current treatment options include liver transplantation or surgical resection, while first-line chemotherapeutic agents include sorafenib, lenvatinib, … phoenix orchestra liverpoolWebb11 nov. 2014 · SIN3B, the SASP, and pancreatic cancer Cellular senescence is classically considered a tumor suppressive mechanism. In addition to having stably exited the cell … phoenix orange beach ii 1702WebbExpression of SIN3B (KIAA0700) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. We use cookies to enhance the usability … ttp orrWebb13 aug. 2012 · We show that Sin3A is downregulated in a variety of human tumors and that Src, JNK, RhoA and PP1B/β-Catenin are regulated in a manner analogous to our … phoenix orange beach condos homeaway