WebOct 22, 2024 · The IRF3, IRF7, MAVS and STING mutant plasmids were generated by site-directed mutagenesis using PfuUltra II Fusion DNA polymerase (Agilent) following the manufacturer’s instructions. IRF3 is a member of the interferon regulatory transcription factor (IRF) family. IRF3 was originally discovered as a homolog of IRF1 and IRF2. IRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain, a C-terminal IRF association domain and several regulatory phosphorylation sites. IRF3 is found …
RCSB PDB - 3DSH: Crystal structure of dimeric interferon …
WebApr 12, 2024 · It was found that TMEM173 N153S mutation triggers lung inflammation independently of cGAS and IRF3, which mainly increases the phosphorylation of STAT1 in T lymphocytes, thereby increasing the transcription of ISG such as Cxcl10 and leading to autoimmune disease (96–98, 101, 102). WebIRF3 → Interferon regulatory factor 3 (IRF-3) Gene name : IRF3 Family name : IRF Entry whose protein (s) existence is based on evidence at protein level. Show evidences Annotations in this section apply to all the isoforms if not specified otherwise. OVERVIEW is the man shake good for you
Interferon Regulatory Factor 9 Structure and Regulation
WebFeb 28, 2008 · In TV7 cells, mutants C164S and C267S have similar transactivation ability as the wild-type IRF3. Mutation of cysteines 222 or 347 resulted in 25 and 30% lower activation, respectively. Mutation of cysteines 289 and 371 resulted in 50% loss of the transactivation ability of the molecule, respectively (Supplementary data, Supplementary Figure S4 ... WebMar 6, 2012 · Two mutations, S366A and L374A, completely abolished IRF3 dimerization, whereas other mutations were largely tolerated ( Fig. 4A ). Of note, the S358A mutant, which was reported to be functionally defective ( 19 ), was partially active in causing IRF3 dimerization in our in vitro assay. WebOct 27, 2024 · Interferon regulatory factor 3 (IRF3) plays a critical role in the innate immune response to viral infection. However, the role of IRF1 in innate immunity remains largely … is the mantle made of iron and nickel