Endoplasmic reticulum stress and atf3
Activating transcription factor 3 (ATF3) is a member of the ATF/cAMP response element-binding (CREB) family, which binds to the cyclic AMP response element (CRE) in numerous promoters with the consensus sequence TGACGTCA (1, 2). Besides, other sequences of ATF3 binding site on the target … See more ATF3 is involved in glucose metabolism in a variety of organs and tissues, including the pancreas, liver, adipose tissue, hypothalamus, and … See more ATF3 is upregulated in the WAT of obese mice (36). ATF3 can downregulate the expression of C/EBPα (37) or PPARγ (38), resulting in suppression of adipocyte differentiation. Kim et … See more Elevated expression levels of ATF3 have been noted in normal human prostate tissue and the androgen-dependent prostate cancer cell line LNCap, but weak expression levels of … See more ATF3 induction has been observed in response to a broad range of Toll-like receptors (TLRs), including TLR4, 2/6, 3, 5, 7, and 9 (3). Consequently, ATF3−/− primary … See more WebJan 1, 2016 · Response to Endoplasmic Reticulum Stress: The Unfolded Protein Response. The ER is the first compartment of the secretory pathway and is responsible …
Endoplasmic reticulum stress and atf3
Did you know?
WebOct 23, 2024 · Here, we showed that DDX3 positively regulates ATF4 mRNA expression during ER stress induced by Sor treatment of cancer cells. We found that DDX3 drives stress-induced ATF4 mRNA … WebSep 8, 2015 · CHOP and ATF3 are closely connected to ER stress-related apoptosis. Therefore, we sought to find the relationship between ER stress and chaetocin. ...
WebMay 20, 2014 · We further show that small molecule inhibition of system x c− function leads to endoplasmic reticulum (ER) stress, as indicated by the transcriptional upregulation of genes linked to the ER stress response. WebSelect search scope, currently: articles+ all catalog, articles, website, & more in one search; catalog books, media & more in the Stanford Libraries' collections; articles+ …
WebJul 18, 2024 · The most highly significant up-regulated genes (FDR < 10 −5) were related to apoptosis followed closely by endoplasmic reticulum stress and unfolded protein response (FDR < 10 −4). Markers of the unfolded protein response (ATF3, ATF4, and DDIT3—also referred to as CHOP) were retested by qRT-PCR and their mRNA levels … WebIntracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals
WebAug 14, 2024 · Multiple extracellular signals, such as endoplasmic reticulum (ER) stress, cytokines, chemokines, and LPS, are connected to ATF3 induction. The function of …
WebJan 27, 2024 · The most highly populated network was the endocannabinoid cancer inhibition pathway, which contains genes that play critical roles in controlling endoplasmic reticulum (ER) stress such as cyclic ... link navigator softwareWebamino acid deprivation or the endoplasmic reticulum stress response (ERSR)1 pathway, also known in yeast as the un-folded protein response, converges on the same set of … link navigator buffalo downloadWeb开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 houppa mariageWebJan 23, 2024 · Wei, Y., Sun, L., Liu, C. et al. Naringin regulates endoplasmic reticulum stress and mitophagy through the ATF3/PINK1 signaling axis to alleviate … linknavigator ダウンロード windows11WebThe endoplasmic reticulum (ER) is the major organelle responsible for secretory protein synthesis, folding and quality control. To maintain ER homeostasis during the stresses … houppe namurWebATF3 is also a stress-inducible gene. Overwhelming evidence from many laboratories indicates that ATF3 is induced by a variety of stress signals. linknbuild.comWebEndoplasmic reticulum (ER) stress and unfolded protein response (UPR) effectors in immune cells. ER stress can modulate the biology of various subsets of immune cells such as cell apoptosis, cytokine production, cell … link navigator windows10