Cyp46a1 protein
WebRecombinant Human CYP46A1 Protein [H00010858-Q01] - 12.5% SDS-PAGE Stained with Coomassie Blue. Product Details. Summary. Reactivity: Hu Species Glossary: Applications: WB, ELISA, PA, AP: Order Details 100% Guarantee on every product. Recombinant Human CYP46A1 GST (N-Term) Protein Summary ... • Human CYP46A1 genome location and CYP46A1 gene details page in the UCSC Genome Browser. • UniProt entry on Cholesterol-24 hydroxylase • HMDB Database entry • RCSB Protein Data Bank Entry
Cyp46a1 protein
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WebJan 1, 2024 · Consistent with HMGCR, CYP46A1 protein level was up-regulated in response to Aβ treatment. Based on our findings, we can suggest that increased expression of CYP46A1 level can be a regulatory positive feedback to keep neurons active in order to inhibit cholesterol accumulation in case of increased levels of HMGCR protein and … WebMar 6, 2024 · Increased bile acid levels in the brain activated FXR signaling, which downregulated the expression of brain Cyp46A1 (catalyzes the synthesis of 24(S)-hydroxycholesterol) in mice (Fig. 7) . Open in a separate window ... Takeda G protein receptor 5 (TGR5) is a cell-surface G protein coupled receptor, ...
WebCYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease CYP46A1 inhibition, brain cholesterol accumulation and … WebCYP46A1 belongs to cytochrome P450 family of enzymes and it localize to ER/microsomes as single-pass membrane protein, and unlike other cytochrome P450 sterol hydroxylases that are predominantly expressed …
WebThe Cyp46a1 gene, which encodes cholesterol 24-hydroxylase, is expressed in only a small but specific subset of neurons in the brain. It was recently found that mice … WebPROTEIN SUMMARY SECTION OVERVIEW RNA DATA. CYP46A1 INFORMATION. Proteini. Full gene name according to HGNC. Cytochrome P450 family 46 subfamily A …
WebSep 22, 2024 · CYP46A1. cytochrome P450 family 46 subfamily A member 1. Gene ID: 10858, updated on 22-Sep-2024. Gene type: protein coding. Also known as: CP46; …
WebCytochrome P450 46A1 (CYP46A1) is a microsomal enzyme and cholesterol 24-hydroxylase that controls cholesterol elimination from the brain. This P450 is also a potential target for Alzheimer disease because it can be activated pharmacologically by some marketed drugs, as exemplified by efavirenz, the anti-HIV medication. Previously, we … candice huffine torridWebCholesterol 24-hydroxylase (CH24H or CYP46A1) is a brain-specific cytochrome P450 enzyme that metabolizes cholesterol into 24S-hydroxycholesterol (24HC) for regulating brain cholesterol homeostasis. fish pass design ukWebMar 21, 2024 · CYP46A1 (Cytochrome P450 Family 46 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP46A1 include Alzheimer Disease, Familial, 1 and Cerebrotendinous Xanthomatosis . Among its related pathways are Oxidation by … FASN (Fatty Acid Synthase) is a Protein Coding gene. Diseases associated with … CYP1A2 (Cytochrome P450 Family 1 Subfamily A Member 2) is a Protein … ACE (Angiotensin I Converting Enzyme) is a Protein Coding gene. Diseases … SLC7A5 (Solute Carrier Family 7 Member 5) is a Protein Coding gene. Diseases … NOX4 (NADPH Oxidase 4) is a Protein Coding gene. Diseases associated with … FDFT1 (Farnesyl-Diphosphate Farnesyltransferase 1) is a Protein … CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1) is a Protein … ACHE (Acetylcholinesterase (Cartwright Blood Group)) is a Protein Coding gene. … PLAU (Plasminogen Activator, Urokinase) is a Protein Coding gene. Diseases … candice lerae cagematchWebApr 18, 2024 · CYP46A1 transcription was found to be insensitive to major regulatory axes, except oxidative stress . Studies show that CYP46A1 may be controlled epigenetically … fish pass diglisfish passes design dimensions and monitoringWebJul 7, 2024 · CYP46A1 controls cholesterol elimination and turnover in the brain, the two processes that determine the rate of brain sterol flux through the plasma membranes and thereby the properties of these membranes. ... Further studies are required to determine whether protein acetylation is affected by CYP46A1 activity or brain sterol flux. The … candice king it\u0027s always the innocent onesWebJul 9, 2024 · CYP46A1 improves behavioural and neuropathological phenotype in zQ175 mice In the zQ175 mice, a knock-in mouse model of Huntington’s disease with a … candice laubach geisinger